- Clb1 Clb2 Mutants
- clb1∆ clb2∆
- CLB1 clb2∆
- CLB1 clb2∆ cdh1∆
- CLB1 clb2∆ pds1∆
- TAB6-1 CLB1 clb2∆
- CLB2-db∆
- CLB2-db∆ in galactose
- CLB2-db∆ multicopy SIC1
- CLB2-db∆ GAL-SIC1
- CLB2-db∆ multicopy CDC6
- CLB2-db∆ GAL-CDC6
- CLB2-db∆ clb5∆
- CLB2-db∆ clb5∆ in galactose
- GAL-CLB2
- Multicopy GAL-CLB2
- GAL-CLB2 sic1∆
- GAL-CLB2 cdh1∆
- APC-A GAL-CLB2
- swi5∆ GAL-CLB2
- cln1∆ cln2∆ cln3∆ GAL-CLB2
- GAL-CLB2-db∆
CLB1 clb2∆ pds1∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksb2'=0.0003, ksb2"=0.013 (=33% of WT), kspds1"=ks2pds"=0.
Experiments:
Shirayama, M., Toth, A., Galova, M. and Nasmyth, K. (1999). APC(CDC20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402:203-207.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Inviable.
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We would expect that, in the absence of Clb2, Cdc5 activation would be delayed even longer, which should not cause problems for pds1∆ cells. We will not be able to account for this mutant until we understand better the roles of Cdc5 and Clb1 in mitotic events.